Serum matrix metalloproteinase-9 and advanced glycation end-products in diabetic patients with or without diabetic foot problems

VernacularTitle:血清基质金属蛋白酶9、糖基化终产物与糖尿病足的相关研究
Author: Zhihong LI ; Hui FANG ; Yunliang ZHANG ; Shuqin GUO ; Jinku ZHANG ; Haiyan LI ; Yanfeng ZHEN ; Yue YANG
Publication Type:Journal Article
Keywords: Diabetic foot; Ulcer; Matrix metalloproteinase-9; Glycation end-products,Advanced
From: Chinese Journal of Endocrinology and Metabolism 2010;26(12):1061-1062
CountryChina
Language:Chinese
Abstract: Serum matrix metalloproteinase-9 (MMP-9)and advanced glycation end products (AGE)levels were measured in the diabetic patients with or without foot problems as well as in healthy retired people. In diabetic patients serum MMP-9 and AGE levels were significantly higher than those in healthy subjects. Median MMP-9 level in patients with diabetic foot was higher than that in diabetic patients without foot ulcers. Increased serum MMP-9 in diabetes might predict occurance of diabetic foot and poor wound healing of the foot ulcers.