Efect of recombinant tissue-type plasminogen activator combined with mild hypothermia for acute cerebral infarctions

VernacularTitle:重组组织型纤溶酶原激活物联合亚低温治疗急性脑梗死36例分析
Author: Yang TAO
Publication Type:Journal Article
Keywords: Tissue-type Plasminogen Activator; Cerebral infarction; thrombolysis
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(23):3183-3185
CountryChina
Language:Chinese
Abstract: Objective To evaluate the efficacy of recombinant tissue-type plasminogen activator(rt-PA)and mild hypothermia for acute cerebral infarctions. Methods72 patients consistent with the inclusion criteria were randomly divided into 2 groups,hypothermia group receivied rt-PA combined with mild hypothermia and control group receiving rt-PA only.Neurological functions was evaluated with European Stroke Scale(ESS). ResultsAs intravenous thrombolytic therapy within 6h after the onset,the ESS scores examined 3 days after thrombolysis in hypothermia group was significantly higher than those in control group.As intravenous thrombolytic therapy during 6h to 12h after the onset,the ESS scores of hypothermia group increased more significantly from 24h after thrombolysis than those in control group. Conclusionft-PA combined with mild hypothermia was more effective than rT-PA only for acute cerebral infarctions,which was effective and relatively safe in the treatment of acute ischemic cerebral vascular disease.