Relationship between plasma membrane glycoprotein gene and obesity, type 2 diabetes mellitus, insulin resistance in Chinese population
10.3760/cma.j.issn.1008-1372.2010.12.011
- VernacularTitle:浆细胞膜糖蛋白-1基因与肥胖、糖尿病关系的群体水平研究
- Author:
Yuanyuan ZHOU
;
Fengjuan QIAN
;
Jie CHEN
;
Zhenhua TIAN
;
Jie SHEN
- Publication Type:Journal Article
- Keywords:
Plasma cells/ME;
Glycoproteins/ME;
Obesity/ME/ET;
Diabetes mellitus/ME/ET
- From:
Journal of Chinese Physician
2010;12(12):1616-1619
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the plasma membrane glycoprotein ( PC-1 ) gene and obesity, type 2 diabetes mellitus, insulin resistance in Chinese population. Methods 53 norma1 subjects, 105 simple obesity subjects, 63 type 2 diabetic patients and 114 obesity type 2 diabetics have been genotyped with PCR-RFLP. Results The frequency of PC-1 gene Q allele was 3%, 18%, 4% and 30% in control, obesity subjects, diabetic patients and obesity diabetic individuals, respectively. Compared with control group, the relative risk (RR) in OB group, OBH grop, OBI group, OBL group and OBHIL group was 4. 26,4. 12,7. 36,5. 15 and 9. 70, respectively. Compared with diabetes group, the RR in diabetes with DMOB, diabetes with OBH group, diabetes with OBI group, diabetes with OBL group and diabetes with OBHIL group was 5.23,7. 37,12. 07,8. 53 and 13. 50, respectively. Concluision The frequency of PC-1 gene Q allele were significantly associated with obesity, obesity diabetics and insulin resistance in Chinese. The results suggested that the PC-1 gene Q allele was a potential genetic marker for obesity, type 2 diabetes and insulin resistance.
