Combination of taurine with silybin meglumine in treatment of patients with non-alcohlic steatohepatitis
10.3760/cma.j.issn.0254-1432.2010.07.003
- VernacularTitle:牛磺酸联合水飞蓟宾葡甲胺治疗非酒精性脂肪性肝炎
- Author:
Xin ZENG
;
Yong LIN
;
Xia SHENG
;
Yiping WANG
;
Yuexiang CHEN
;
Weifen XIE
;
Weizhong CHEN
- Publication Type:Journal Article
- Keywords:
Fatty liver,alcoholic;
Taurine;
Silybin
- From:Chinese Journal of Digestion
2010;30(7):441-443
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the therapeutic effects of taurine combined with silybin meglumine in patients with non-alcoholic steatohepatitis (NASH). Methods One hundred patients with NASH were divided into two groups with 50 for each. The patients in the control group received polyene phosphatidyl choline (456 mg) combined with silybin meglumine (100 mg) 3 times daily for 24 weeks. While those in the treatment group received taurine (2 g) combined with silybin meglumine (100 mg) 3 times daily for 24 weeks. All patients were asked to take up basic therapy including drinking without alcohol, restricting sugary and fatty intake, improving food structure, carrying moderate aerobics and lightening body weight. Results At the end of 24 weeks, the clinical symptoms and the liver function ameliorated in two groups. Ultrasonic or CT examination showed that the steatohepatitits was improved significantly in two groups. Additionally, the levels of blood glucose, serum triglyceride and cholesterol as well as BMI decreased simultaneously (all P value <0. 05). Whereas the treatment group was superior to control group in aspect of amelioration of inappetite, nausea and vomiting as well as lever of serum triglyceride (all P value <0. 05). There was no side effect in the treatment group. Conclusion Based on the basic therapy, taurine combined with silybin meglumine can mitigate the degree of NASH, improve the metabolism of blood glucose and lipid with few side-effects.
