Effects of G. Pentaphyllumon on photoaging skin in nake mice

VernacularTitle:绞股蓝对光老化皮肤组织的影响
Author: Hongbo ZHOU ; Wei WU ; Shihan WANG ; Jingdong WU
Publication Type:Journal Article
Keywords: G. Pentaphyllum; Skin; Photoageing; Oxidative damage
From:Chinese Journal of Medical Aesthetics and Cosmetology 2010;16(6):401-403
CountryChina
Language:Chinese
Abstract: Objective To investigate G. Pentaphyllums influence on the activity of glutathione peroxidase (GSH-PX) and catalase (CAT) in the skin of hireless photoaging mice, as well as the content of hydroxyproline (HYP). At the same time, G. Pentaphyllum's effect on the hireless photoaging mice was studied. Methods Healthy KM hireless mice were randomly divided into five groups. A skin photoaging model was established by G. Pentaphyllum administration. The changes of the activity of GSH-PX, CAT and the contents of dermal hydroxyproline in the skin were then measured by biochemical methods in each group of the experiment. Results In the model group, the activity of GSHPX, CAT and the content of HYP of skin were all decreased significantly (P＜0. 05). And there were different degrees of improvements in those of the herb given groups. Conclusion G. Pentaphyllumhas the protective effect on the skin of the photoageing in the hairless mice. The mechanism may be that G. Pentaphyllum could inhibit the oxidative damages of ultraviolet and skin photoaging by increasing the synthesis of collagen in skin.