Study the hepatoprotective effect of panax notoginseng on CCl4 and PAR - intoxicated rat liver
- Author:
Duong Thi Ly Huong
- Publication Type:Journal Article
- Keywords:
Experimental hepatitis
- MeSH:
Panax notoginseng;
Carbon Tetrachloride;
poisoning;
liver;
rats;
Animal Experimentation
- From:Journal of Medical Research
2004;27(1):39-45
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Two rat hepatic intoxication models by high doses CCl4 and PAR were used. The experimental results showed that the oral administration of Panax Notoginseng (aqueous extract) with the dose of 5g/kg body weight has significantly reduced the serum concentrations of SGOT and SGPT with 29.1% and 43.1% respectively in comparison with that of CCl4 - treated control . In PAR - intoxicated group, Panax Notoginseng with the dose of 5g/kg body weight resulted in a marked decrease of SGOT and SGPT serum concentration 97.0% and 75.5%, respectively, which were significantly different from that of group without Panax Notoginseng. The hepatoprotective effect of Panax Notoginseng with the dose of 5g/kg and Silymarin with the dose of 25mg/kg on both CCl4 and PAR hepatic-intoxication models is the same. In histopathological examinations, Panax Notoginseng has improved CCl4 and PAR induced hepatic injuries
