Characterization and clinical application of mesenchymal stem cells from equine umbilical cord blood.
10.4142/jvs.2013.14.3.367
- Author:
Jun Gu KANG
1
;
Sang Bum PARK
;
Min Soo SEO
;
Hyung Sik KIM
;
Joon Seok CHAE
;
Kyung Sun KANG
Author Information
1. Department of Veterinary Internal Medicine, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul 151-742, Korea. jschae@snu.ac.kr
- Publication Type:Case Reports ; Research Support, Non-U.S. Gov't
- Keywords:
cell transplantation;
equine;
mesenchymal stem cells;
umbilical cord blood
- MeSH:
Animals;
*Cord Blood Stem Cell Transplantation/veterinary;
Horse Diseases/*surgery;
Horses;
Male;
Tendinopathy/surgery/*veterinary
- From:Journal of Veterinary Science
2013;14(3):367-371
- CountryRepublic of Korea
- Language:English
-
Abstract:
Tendinitis of the superficial digital flexor tendon (SDFT) is a significant cause of lameness in horses; however, recent studies have shown that stem cells could be useful in veterinary regenerative medicine. Therefore, we isolated and characterized equine umbilical cord blood mesenchymal stem cells (eUCB-MSCs) from equine umbilical cord blood obtained from thoroughbred mares during the foaling period. Horses that had tendinitis of the SDFT were treated with eUCB-MSCs to confirm the therapeutic effect. After eUCB-MSCs transplantation, the core lesion in the SDFT was found to decrease. These results suggest that transplantation using eUCB-MSCs could be another source of cell treatment.
