A Clinical Study on Patients with Chronic Lymphocytic Leukemia.
- Author:
Jeon Ho YANG
1
;
Hyeon Soo SHIN
;
Young Sik JUNG
;
Jun Ho WHANG
;
Dong Gun SHIN
;
Sang Kyun SOHN
;
Kyu Bo LEE
;
Kee Suk WHANG
Author Information
1. Department of Internal Medicine, College of Medicine, Catholic University of Taegu-Hyosung, Korea.
- Publication Type:Original Article
- Keywords:
Chronic lymphocytic leukemia
- MeSH:
Bone Marrow;
Cause of Death;
Diagnosis;
Drug Therapy, Combination;
Female;
Follow-Up Studies;
Gyeongsangbuk-do;
Humans;
Korea;
Leukemia;
Leukemia, Lymphocytic, Chronic, B-Cell*;
Lymphocyte Count;
Male;
Medical Records;
Prognosis;
Retrospective Studies
- From:Journal of the Korean Cancer Association
1997;29(6):1106-1113
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Chronic lymphocytic leukemia (CLL) is the most common form of leukemia in western countries but it has been reported rarely in Korea. The purpose of this study was to evaluate the clinical characteristics, treatment responses and prognosis of the patients with CLL. MATERIALS AND METHODS: We retrospectively reviewed the medical records of 17 patients with CLL diagnosed at the Catholic University of Taegu-Hyosung & Kyungpook National University Hospital from Jan. 1986 to Mar. 1996. RESULTS: There were 9 males and 8 females and the mean age was 55 years. The majority of patients had systemic symptoms (77%) and advanced clinical stage (Binet stage C, 70%) at the time of diagnosis. The bone marrow histology was reviewed in 13 cases and patients were subdivided into those with a diffuse (9cases) and nondiffuse (4cases) pattern of bone marrow histology. In patients with advanced clinical stage, diffuse pattern was predominated and showed poor survival. 14 patients were treated with chlorambucil/steroid or combination chemotherapy. Among the 13 evaluable patients, 1 (8%) achieved a complete response and 7 (54%) achieved partial responses, and median survival duration was 18months. 11 patients died after 2~18 months of follow-up and infection was the main cause of death. CONCLUSION: Poor prognostic factors, such as high blood lymphocyte counts, diffuse bone marrow involvement pattern & advanced clinical stage, are common in our patients at presentation & showed poor survival.
