Some models of experimental hyperglycemia applying to screening and evaluating the therapeutic effect of antidiabetic drugs
- Author:
Huong Thanh Phung
- Publication Type:Journal Article
- Keywords:
antidiabetic drug
- MeSH:
Hyperglycemia;
Hypoglycemic Agents;
Pharmaceutical Preparations;
therapeutics
- From:Pharmaceutical Journal
1999;282(10):16-18
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
In this study, we have carried out a verification of 3 hyperglycemic models to confirm their potential application and to determine a suitable dose for each hyperglycemic agent. Results from our verification showed that the following hyperglycemic models can be used in screening and evaluating hypoglycemic action of natural products: hyperglycemic action using oral glucoses at 3g/kg. Hyperglycemic action using IM Adrenalin at 0.5 mg/kg. Hyperglycemic action using IV Streptozocin, at 70mg/kg causing human type II diabetes, at 100 m/kg causing human type I diabetes.
