Antiphospholipid Syndrome and Vascular Ischemic (Occlusive) Diseases: An Overview.
10.3349/ymj.2007.48.6.901
- Author:
Penka A ATANASSOVA
1
Author Information
1. Department of Neurology, Medical University, 15A V. Aprilov Blvd., Plovdiv, 4000, Bulgaria. pp_atanassova@yahoo.com
- Publication Type:Review
- Keywords:
Antiphospholipid syndrome;
antiphospholipid antibodies;
ischemic;
occlusive;
neurological;
classifications;
etio-pathogenesis;
criteria
- MeSH:
Antibodies, Antiphospholipid/immunology;
Antiphospholipid Syndrome/diagnosis/*immunology/therapy;
Arterial Occlusive Diseases/diagnosis/*immunology/therapy;
Cerebrovascular Disorders/diagnosis/immunology/therapy;
Humans;
Lupus Erythematosus, Systemic/diagnosis/immunology/therapy
- From:Yonsei Medical Journal
2007;48(6):901-926
- CountryRepublic of Korea
- Language:English
-
Abstract:
Antiphospholipid syndrome (APS) is primarily considered to be an autoimmune pathological condition that is also referred to as "Hughes syndrome". It is characterized by arterial and/or venous thrombosis and pregnancy pathologies in the presence of anticardiolipin antibodies and/or lupus anticoagulant. APS can occur either as a primary disease or secondary to a connective tissue disorder, most frequently systemic lupus erythematosus (SLE). Damage to the nervous system is one of the most prominent clinical constellations of sequelae in APS and includes (i) arterial/ venous thrombotic events, (ii) psychiatric features and (iii) other non- thrombotic neurological syndromes. In this overview we compare the most important vascular ischemic (occlusive) disturbances (VIOD) with neuro-psychiatric symptomatics, together with complete, updated classifications and hypotheses for the etio-pathogenesis of APS with underlying clinical and laboratory criteria for optimal diagnosis and disease management.
