Progress on strategies to promote vascularization in bone tissue engineering.
- Author:
Kai CHEN
;
Chao ZHANG
;
Lu WANG
;
Yu-Yan MAO
;
Jian-Xi LU
;
Lei CHEN
- Publication Type:Journal Article
- MeSH:
Bone and Bones;
blood supply;
Humans;
Neovascularization, Physiologic;
Tissue Engineering;
methods;
Tissue Scaffolds
- From:
China Journal of Orthopaedics and Traumatology
2015;28(4):383-388
- CountryChina
- Language:Chinese
-
Abstract:
With the continuous development of bone tissue engineering, a variety of emerging bone graft materials provided various methods for repairing bone defects. Early and rapid accomplishment of revascularization of materials interior after implantation of bone transplantation materials is a difficulty faced to bone tissue engineering. Blood vessels ingrowth provides the requisite netritional support for the regeneration reconstruction of bone tissue, for this reason, vascularization plays a significant role in bone tissue engineering. However,there is not a golden standard strategy of vascularization at present. Scaffold materials, cells and growth factors still are three indispensable elements in tissue engineering, and are cardinal points of the promoting vascularization strategies. Multiple growth factors or multiple cells combined with scaffolds, which are hot spots, have obtained excellent vascularization. This review focused on the comprehensive strategies for promoting the successful vascularization of tissue engineered scaffolds.
