Relationship between viral genotype and specific and nonspecific CTL of patients with cirrhotic hepatitis B and its significance
10.3760/cma.j.issn.1003-9279.2011.03.017
- VernacularTitle:乙型肝炎肝硬化患者病毒基因型与特异性、非特异性CTL的关系和意义
- Author:
Xi-Bing GU
1
;
Xiao-Juan YANG
;
Juan-Hua WANG
;
Zhong HUA
;
Zhong-Hua LU
;
Yue-Qin XU
;
Zhi-Yuan JIA
Author Information
1. 无锡市传染病医院
- Keywords:
Hepatitis B;
Liver cirrhosis;
Genotype;
T-Lymphocytes,Cytotoxic
- From:
Chinese Journal of Experimental and Clinical Virology
2011;25(3):211-213
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore relationship between different HBV genotypes and peripheral blood HBV specific and nonspecific CTL of patients with cirrhotic hepatitis B and its significance. Methods HBV genotypes were tested in 91 patients with cirrhotic hepatitis B, differences of HBV specific and nonspecific CTL between patients infected with genotype B and C were compared and its significance was explored. Results In 91 cases of cirrhotic hepatitis B, 55 cases (60.44% ) belong to genotype C, 35 cases (38. 46% ) belong to genotype B, 1 case (1. 1% ) belongs to mixture genotype B and C. In genotype C,27 cases (49.09% ) had positive (HLA)-A2, HBV specific CTL was 0. 18% ±0.03%. In genotype B, 18 cases (51.43% ) had positive HLA-A2, HBV specific CTL was 0. 38% ± 0.04% , higher than that in genotype C,t =5. 01, P <0. 01. Nonspecific CTL: genotype C (11. 87% ± 1. 50% ) ; genotype B( 11. 90%± 1. 51% ), t =0. 14, P ＜0. 05. HBV DNA level; genotype C (6. 01 ± 0. 81) log10 copy/ml, higher than that in genotype B (5.01 ± 0.54) log10 copy/ml, t =5.01, P ＜0.01. ALT; genotype C (251. 13 ± 131. 11) U/L, higher than that in genotype B (121. 25 ± 63. 21) U/L, t =3. 61, P <0. 01. TBil (45. 61± 15.11) μmol/L, higher than that in genotype B (28.11 ±6.25) μmol/L, t = 3.05, P ＜ 0.01. Conclusion Compared with patients infected with genotype B of cirrhotic hepatitis B, HBV specific CTL of patients infected with genotype C was lower, resulting in higher level of HBV DNA and more severe damage of liver function.
