A Study of the Effect of a Mixture of Hyaluronic Acid and Sodium Carboxymethyl Cellulose (Guardix-sol(R)) on the Prevention of Pericardial Adhesion.
- Author:
Song Am LEE
1
;
Jin Sik KIM
;
Jun Seok KIM
;
Jae Joon HWANG
;
Woo Surng LEE
;
Yo Han KIM
;
Yang Kyu CHOI
;
Hyun Keun CHEE
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Konkuk University Hospital, School of Medicine, Konkuk University, Korea. cheehk@hanmail.net
- Publication Type:Original Article
- Keywords:
Pericardium;
Adhesion;
Animal model
- MeSH:
Animals;
Azo Compounds;
Carboxymethylcellulose Sodium;
Eosine Yellowish-(YS);
Hyaluronic Acid;
Methyl Green;
Models, Animal;
Pericardium;
Rats;
Sodium
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2010;43(6):596-601
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: This study was designed to evaluate the efficacy of a mixture of hyaluronic acid and sodium carboxymethyl cellulose (Guardix-sol(R)) on experimental pericardial adhesion. MATERIAL AND METHOD: Thirty rats were divided into 2 groups of 15 rats each and pericardial mesothelial injury was induced during surgery by abrasion. In the control group, blood and normal saline were administered into pericardium; in the test group, blood and HA-CMC solution were administered. Pericardial adhesions were evaluated at 2 weeks (n=5), 4 weeks (n=5), and 6 weeks (n=5) after surgery. The severity of adhesions was graded by macroscopic examination, and the adhesion tissue thickness was analyzed microscopically with Masson trichrome stain and an image processing program. RESULT: The test group had significantly lower macroscopic adhesion scores (2.9+/-0.6 : 3.9+/-0.4, p<0.000) compared with the control group. For microscopic adhesion tissue thickness, the test group had lower scores compared with the control group, but this difference was not statistically significant (91.73+/-49.91 : 117.67+/-46.4, p=0.106). CONCLUSION: We conclude that an HA-CMC solution (Guardix-sol(R)) reduces the formation of pericardial adhesions in this animal model.
