The Relationship between the Upright Serum aldosterone Level and the Left Ventricular Geometry in Essentioal Hypertension.
- Author:
Jin Ho SHIN
1
;
Bang Hun LEE
;
Jang Kyun OH
;
Hee Jeong CHOI
;
Sahng LEE
;
Myeong Kon KIM
;
Kyung Tae JUNG
;
Soon Chang PARK
;
Chung Kyun LEE
Author Information
1. Department of Internal Medicine, Eulji University School of Medicine, Daejon, Korea.
- Publication Type:Original Article
- Keywords:
Serum aldosterone;
Essential hypertension;
Left ventricular geometry
- MeSH:
Aldosterone*;
Echocardiography;
Fibrosis;
Heart;
Humans;
Hypertension*;
Hypertrophy, Left Ventricular;
Radioimmunoassay;
Sodium
- From:Journal of the Korean Society of Echocardiography
2002;10(1):58-64
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Aldosterone acts as a non-hemodynamic factors on the hypertensive heart regarding sodium retension or myocardial fibrosis. To elucidate whether aldosterone is associated with the specific left ventricular geometry or not, we investigated the relationship between the upright serum aldosterone levels and the echocardiographicleft ventricular structure in the essential hypertension patients never treated. METHODS: Echocardiographic indices included M-mode measured left ventricular mass index (LVMI), relative wall thickness (RWT). Aldosterone is measured by Radioimmunoassay for the serum withdrawn from the subjects at least 3 hours upright position. 63 patients and 20 normal control subjects were evaluated. RESULTS: 1) 84.1% (63/53) of cases showed left ventricular hypertrophy. 7 patients showed normal LVMI, 3 patients showed concentric remodeling geometry. 19 patients had concentric left ventricular hypertrophy (LVH). 34 patients had eccentric LVH. 2) The serum aldosterone level has negative correlation with the RWT (r=-0.27, p=0.03) but not with LVMI (r=0.08, p=NS). There was difference among groups (ANOVA, F=0.009). Serum aldosterone is higher in eccentric LVH group than in concentric LVH group (10.5+/-1.2 ng/dL vs 5.2+/-0.6 ng/dL, p=0.0001) and than in control group (10.5+/-1.2 ng/dL vs 6.6+/-0.8 ng/dL, p=0.01). CONCLUSION: In this study, we observed that the serum aldosterone level was not correlated with the LVMI but with RWT negatively so that eccentric LVH group showed higher serum aldosterone levels than control group and concentric LVH group.
