A focus on extracellular Ca²⁺ entry into skeletal muscle.
- Author:
Chung Hyun CHO
1
;
Jin Seok WOO
;
Claudio F PEREZ
;
Eun Hui LEE
Author Information
- Publication Type:Review
- MeSH: Contractile Proteins; Cytosol; Extracellular Space; Kinetics; Muscle, Skeletal*; Posture; Relaxation; Sarcoplasmic Reticulum
- From:Experimental & Molecular Medicine 2017;49(9):e378-
- CountryRepublic of Korea
- Language:English
- Abstract: The main task of skeletal muscle is contraction and relaxation for body movement and posture maintenance. During contraction and relaxation, Ca²⁺ in the cytosol has a critical role in activating and deactivating a series of contractile proteins. In skeletal muscle, the cytosolic Ca²⁺ level is mainly determined by Ca²⁺ movements between the cytosol and the sarcoplasmic reticulum. The importance of Ca²⁺ entry from extracellular spaces to the cytosol has gained significant attention over the past decade. Store-operated Ca²⁺ entry with a low amplitude and relatively slow kinetics is a main extracellular Ca²⁺ entryway into skeletal muscle. Herein, recent studies on extracellular Ca²⁺ entry into skeletal muscle are reviewed along with descriptions of the proteins that are related to extracellular Ca²⁺ entry and their influences on skeletal muscle function and disease.
