Helicobacter pylori Infection and Peptic Ulcer Disease in Patients with Liver Cirrhosis.
10.3904/kjim.2008.23.1.16
- Author:
Dong Joon KIM
1
;
Hak Yang KIM
;
Sung Jung KIM
;
Tae Ho HAHN
;
Myoung Kuk JANG
;
Gwang Ho BAIK
;
Jin Bong KIM
;
Sang Hoon PARK
;
Myung Seok LEE
;
Choong Kee PARK
Author Information
1. Department of Internal Medicine, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon, Korea. djkim@hallym.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Helicobacter pylori;
Liver cirrhosis;
Peptic ulcer
- MeSH:
Adult;
Female;
Helicobacter Infections/*complications/*epidemiology;
*Helicobacter pylori;
Humans;
Liver Cirrhosis/*complications;
Male;
Middle Aged;
Prevalence;
Severity of Illness Index;
Stomach Ulcer/*complications/*epidemiology
- From:The Korean Journal of Internal Medicine
2008;23(1):16-21
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: We investigated the prevalence and relationship of peptic ulcer disease and Helicobacter pylori infection to liver cirrhosis. METHODS: We examined 288 patients with liver cirrhosis, 322 patients with non-ulcer dyspepsia, and 339 patients with peptic ulcer disease. Rapid urease test and Wright-Giemsa staining were used for diagnosis of H. pylori infection. RESULTS: The prevalence of peptic ulcer disease in patients with cirrhosis was 24.3%. The prevalence of peptic ulcer disease in patients with cirrhosis divided into Child-Pugh classes A, B, and C was 22.3%, 21.0%, and 31.3%, respectively (p>0.05). The prevalence of H. pylori infection in the patients with cirrhosis, non-ulcer dyspepsia, and peptic ulcer without chronic liver disease were 35.1%, 62.4%, and 73.7%, respectively (p<0.001). The prevalence of H. pylori infection did not differ depending on whether there was peptic ulcer (35.6%) or not (34.9%) in patients with liver cirrhosis (p>0.05). The prevalence of H. pylori infection in patients with hepatitis virus-related liver cirrhosis and in the patients with alcohol-related liver cirrhosis was 42.5% and 22.0%, respectively (p<0.001). The prevalence of H. pylori infection in patients with Child-Pugh classes A, B, and C liver cirrhosis was 51.5%, 30.5%, and 20.0%, respectively (p<0.001). CONCLUSIONS: Factors other than H. pylori may be involved in the pathogenesis of peptic ulcer disease in the setting of liver cirrhosis.
