Meta-analysis of diagnostic efficiency of 99Tc m-PYP SPECT/CT scintigraphy for transthyretin-related cardiac amyloidosis
10.3760/cma.j.cn321828-20230908-00044
- VernacularTitle:99Tc m-PYP SPECT/CT显像对转甲状腺素蛋白相关心脏淀粉样变诊断效能的Meta分析
- Author:
Taiping LIAO
1
;
Yueting SHEN
;
Qinling QI
;
Li LI
;
Guoxu FU
;
Lingxiao LI
;
Yongjun LONG
Author Information
1. 绵阳市第三人民医院、四川省精神卫生中心核医学科，绵阳 621000
- Keywords:
Amyloidosis;
Myocardium;
Radionuclide imaging;
Tomography, emission-computed, single-photon;
Technetium Tc 99m pyrophosphate;
Meta-analysis
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2024;44(8):484-489
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the performance of visual score and heart-to-contralateral lung (H/CL) ratio of 99Tc m-pyrophosphate (PYP) SPECT/CT scintigraphy for diagnosing transthyretin-related cardiac amyloidosis (ATTR-CA) by using Meta-analysis. Methods:Relevant studies on 99Tc m-PYP SPECT/CT diagnosis of ATTR-CA published before August 20, 2023 from databases including Pubmed, EMbase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang and China Science and Technology Journal Database (VIP) were retrieved. Articles were screened and indices which reflect the diagnostic efficiency such as sensitivity and specificity were extracted. Forest plots were drawn, and subgroup analysis was performed to analyze the heterogeneity. Results:A total of 160 articles were retrieved, and 11 articles involving 1 802 patients were enrolled, of whom 605 were diagnosed with ATTR-CA. All 11 articles were enrolled when analyzing the diagnostic efficiency of visual score for diagnosing ATTR-CA. After integration, the sensitivity and specificity were 0.95(95% CI: 0.91-0.97) and 0.95(95% CI: 0.90-0.98), respectively. Ten articles (1 611 patients) were enrolled when analyzing the diagnostic efficiency of H/CL ratio for diagnosing ATTR-CA. After integration, the sensitivity and specificity were 0.93(95% CI: 0.82-0.98) and 0.99(95% CI: 0.90-1.00), respectively. Subgroup analysis indicated that lack of uniformity in diagnostic criteria was the primary source of heterogeneity. Conclusion:99Tc m-PYP SPECT/CT scintigraphy exhibits high diagnostic efficiency for ATTR-CA.
