The effects of amiodarone on QT dispersion in patients with atrial fibrillation
10.3969/j.issn.1007-7693.2000.03.029
- VernacularTitle:胺碘酮转复心房纤颤时对QT离散度影响
- Author:
Yong SUN
1
;
Hong HE
;
Duan LU
Author Information
1. 浙江大学附属邵逸夫医院
- Keywords:
amiodarone;
atrial fi brillation;
QT dispersion;
QT interval
- From:
Chinese Journal of Modern Applied Pharmacy
2000;17(3):234-236
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:This study evaluated the eff ects of amiodarone on the myocardial repolarization in the patients with atrial fibrillation.METHODS:QT dispersions measured from 12-lead standard surface ECG were retrospectively assessed in 48 patients treated with Amiodarone ,and compared with that of paroxysmal atrial fibrillation and health groups.RESULTS:No disparity in QT interval and QT dispersion was found between paroxysmal atrial fibrillation and health group(QT:405±44vs397+30ms.QTc:448±47 vs424±26ms,QTD 29±17vs27±16ms,QTcD:28±19vs26±18ms,P>0.05). However,compared with these two group,we found that both of the QT interval and QT dispersion significantly increased in Amiodarone group(QT:465±53vs405±44 or 397±30ms,QTc:449±54vs448±47 or 424±26ms,QTD:47±20vs29±19 or 27±16ms,QTcD :49±21vs28±19 or 26±18ms,P<0.01).CONCLUSION:Amiodaro ne not only effectively control atrial fibrillation with QT interval prolongatio n but also increased QT dispersion.
