Influence of transfusion of lactated Ringer's solution on arterial blood lactate concentration and acid-base balance during orthotopic liver transplantation
10.3760/cma.j.issn.1674-2907.2008.13.008
- VernacularTitle:原位肝移植病人术中输入乳酸林格氏液对动脉血乳酸浓度及酸碱平衡的影响
- Author:
Lan-Qin DENG
1
;
Yong-Hong DING
;
Dong-Hua LIU
Author Information
1. 山东省聊城市人民医院
- Keywords:
Liver transplantation;
Blood lactate;
Acid-base balance
- From:
Chinese Journal of Modern Nursing
2008;14(13):1457-1459
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of transfusing two different crystalloid solution on arterial blood lactate and acid-base balance among patients with orthotopic liver transplantation. Methods 60 patients with liver cancer, or other end-stage liver disease were observed. These patients were randomly divided into group A and group B according to the crystalloid solution. Lactated Ringer' s solution was transfused to patients in group A, and physiological saline to patients in group B during the operation. CoUoid solution and blood product were supplied according to the intra-operative changes of blood pressure and central venous pressure of patients during the operation. The arterial blood was collected before the operation, at the time of portal vein occlusion, 30 minutes after liver removed, at the time of unclamping of portal vein, 30 minute after unclamping of inferior vena cava and when the operation completed, respectively. Then the pH, base excess (BE) and lactic acid (LA) were measured. Results The differences of input quantity of crystalloid, colloid solution and blood product had no statistical meaning between the two groups (P<0.05). Compared to those before the operation, the pH values after liver removed decreased and continued to the completion of operation in the two groups (P<0.05). BE decreased obviously 30 minutes after liver removed (P<0.05). The concentration of LA began to rise before liver removed and continued to the completion of operation. This phenomenon of LA concentration was especially obvious after the new liver opened, and the concentration was increased by about 3 times compared to that before the operation (P<0.01). Each index of the two solutions had no statistical meaning at each time point (P>0.05). Conclusions Transfusion of lactated Ringer' s solution has no remarkable influence on the increasing trend of arterial blood lactate concentration and the acid- base balance during orthotopic liver transplantation.
