Clinical study of methylprednisolone combined with azithromycin in the treatment mycoplasma pneumonia in children
10.13699/j.cnki.1001-6821.2015.10.001
- VernacularTitle:阿奇霉素联合甲泼尼龙治疗肺炎支原体肺炎患儿的临床研究
- Author:
Hua-Jun LI
1
;
Xiao-Hong CHEN
;
Hang-Hu ZHANG
;
Chang-Feng DONG
Author Information
1. 绍兴市人民医院儿科
- Keywords:
methylprednisolone;
azithromycin;
children;
mycoplasma pneumonia;
clinical efficacy
- From:
The Chinese Journal of Clinical Pharmacology
2015;(10):771-773
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effects and adverse reactions of methylprednisolone combined with azithromycin for the treat-ment of mycoplasma pneumonia .Methods A total of 80 children with mycoplasma pneumonia were recruited and randomized divided into treat-ment and control group , with 40 cases in each group.Children in the control group were given azithromycin 10 mg? kg -1 through intravenous infusion , qd for 7 days.Children in the treatment group were given met-hylprednisolone 2 mg? kg -1 through intravenous infusion bid combined with azithromycin , and after the temperature returned to normal condi-tion, children were given prednisone tablet 1 mg? kg -1 for 5 days.The data of clinical efficacy , time that symptoms disappeared and adverse drug reactions between the two groups were compared .Results The total clinical efficacy were 90.0%and 80.0%in the treatment and con-trol group , respectively , indicating no statistical difference between the two groups ( P<0.05 );but the symptoms were much shorter than those in control group, such as cough [(4.21 ±1.55) vs (5.19 ±1.36)d], fever [ ( 8.37 ±2.13 ) vs ( 11.99 ±1.25 ) d ] and hospital stay [ ( 11.21 ±2.65 ) vs ( 15.25 ±3.22 ) d ] ( P <0.05 ) .There was no significant difference in adverse drug reactions ( 17.5% vs 12.5%) between the two groups ( P>0.05 ) .Conclusion Methylprednisolone combined with azithromycin can quickly im-prove the symptoms in children with mycoplasma pneumonia , without increasing adverse drug reactions .
