Autophagy Abnormalities in PCOS and Targeted Treatment with Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20241894
- VernacularTitle:PCOS中的自噬异常及中医药靶向干预的研究进展
- Author:
Xinxin YANG
1
;
Zhicheng JIA
1
;
Mengyu SHI
1
;
Yongqian LI
1
;
Peixuan WANG
1
;
Ying GUO
2
Author Information
1. The First Clinical Medical College of Shandong University of Traditional Chinese Medicine（TCM），Jinan 250014，China
2. Affiliated Hospital of Shandong University of TCM，Jinan 250011，China
- Publication Type:Journal Article
- Keywords:
polycystic ovary syndrome （PCOS）;
autophagy;
signaling pathway;
regulatory factor;
mechanism;
traditional Chinese medicine（TCM） formula;
TCM extract
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(3):313-322
- CountryChina
- Language:Chinese
-
Abstract:
Polycystic ovary syndrome （PCOS） is a common gynecological endocrine and reproductive disorder，with the main clinical manifestations including ovulation failure，insulin resistance，hyperandrogenism，and obesity. Its occurrence and development are closely related to cellular regulatory mechanisms such as apoptosis，autophagy，oxidative stress，and inflammatory response. Autophagy，as a clearance mechanism that maintains cellular homeostasis，plays a crucial role in maintaining the growth，development，and maturation of oocytes. Exploring the mechanism of autophagy during the occurrence and development of diseases can help develop treatment methods for PCOS by regulating autophagy. Studies have shown that autophagy plays an important role in the pathogenesis of PCOS，and it can affect the occurrence and development of PCOS through multiple pathways，levels，and targets. Traditional Chinese medicine （TCM） regulates autophagy in ovarian granulosa cells or endometrium of patients with PCOS by targeting the expression of autophagy signaling pathways，regulatory factors，and non-coding single-stranded RNA molecules，thereby alleviating inflammation，regulating metabolism disorders，and balancing hormone levels in PCOS. Accordingly，TCM can ameliorate pathological conditions such as insulin resistance，hyperandrogenism，and ovulation failure in PCOS. This article summarizes the TCM formulas and extracts for the treatment of PCOS，as well as the main autophagy pathways and regulatory factors involved，aiming to provide reference and suggestions for the future treatment of PCOS with TCM by regulating autophagy.
