Research advances on the pathogenesis and treatment of unexplained recurrent spontaneous abortion
- VernacularTitle:不明原因复发性流产发病机制及治疗方法的研究进展
- Author:
Dongyuan LU
1
;
Jianfeng JIN
1
;
Weiwei LUO
1
;
Qilei QIAN
2
;
Xiaoya WEN
2
Author Information
1. Dept. of Pharmacy，Ningbo Sixth Hospital，Zhejiang Ningbo 315040，China
2. Dept. of Pharmacy，Guiyang Fourth People’s Hospital，Guiyang 550007，China
- Publication Type:Journal Article
- Keywords:
unexplained recurrent spontaneous abortion;
pathogenesis;
therapies;
immune
- From:
China Pharmacy
2024;35(17):2188-2192
- CountryChina
- Language:Chinese
-
Abstract:
Spontaneous abortion is one of the most common complications of pregnancy， and two or more spontaneous abortions in a row are defined as recurrent spontaneous abortion （RSA）， of which about half of patients have unknown etiology. However， the pathogenesis of unexplained RSA （URSA） has not been elucidated， and the lack of effective treatment has made it one of the key and difficult points in the field of obstetrics and gynecology. This article conducts a literature review of recent research on URSA and finds that the pathogenesis of URSA is related to the imbalance of immune tolerance at the maternal-fetal interface， apoptosis of trophoblast cells， inhibition of angiogenesis， and activation of immune responses. Immunotherapy （including cell therapy， cytokine therapy， and immunosuppressive intervention）， hormone drugs， anticoagulant regimens， and traditional Chinese medicine therapies are commonly used in clinical practice to intervene in URSA， but the safety and effectiveness of some therapies are still controversial.
