Research progress on the effects,mechanisms and intervention strategies of exercise on neural injury in methamphetamine addicts
10.7683/xxyxyxb.2024.02.016
- VernacularTitle:运动对甲基苯丙胺成瘾者神经损伤的影响及机制和干预策略研究进展
- Author:
Chen LI
1
;
Jun LIU
Author Information
1. 西安体育学院研究生部,陕西 西安 710068
- Keywords:
methamphetamine;
exercise intervention;
oxidative stress;
inflammatory response;
blood-brain barrier
- From:
Journal of Xinxiang Medical College
2024;41(2):191-196
- CountryChina
- Language:Chinese
-
Abstract:
Currently,methamphetamine(MA)has become the most commonly abused synthetic stimulant.The long-term use of MA has resulted in serious mental disorders and cognitive impairments,posing significant public health and social issues both domestically and internationally.As a novel adjunctive therapy,exercise intervention can effectively mitigate the neuro-structural and functional injury caused by MA by suppressing neural oxidative stress,reducing inflammatory factors and cellular apoptosis levels,restoring glutamate/gamma-aminobutyric acid homeostasis and blood-brain barrier function,and promoting neuroplasticity.Exercise intervention also contributes to decreasing drug cravings,enhancing physical fitness,alleviating with-drawal symptoms,and reducing negative subjective emotions among addicts.Therefore,scientifically tailored exercise interven-tion programs with abundant types of sports and personalized exercise programs designed based on the physical and mental conditions of individuals with addiction can lead to better intervention outcomes and reduce the risk of relapse.This paper provides a comprehensive review of the research progress on the effects,mechanisms and intervention strategies of exercise on neural injury in MA addicts,aiming to provide evidence for the application of exercise intervention in drug withdrawal programs for MA addicts.
