Traditional Chinese Medicine Treats Cardiovascular Diseases by Regulating Mitochondrial Membrane Potential： A Review
10.13422/j.cnki.syfjx.20232325
- VernacularTitle:中医药干预线粒体膜电位治疗心血管疾病的研究进展
- Author:
Jingzhuo MA
1
;
Yuqing TAN
1
;
Hengwen CHEN
1
Author Information
1. Guang'anmen Hospital， China Academy of Chinese Medical Sciences， Beijing 100053， China
- Publication Type:Journal Article
- Keywords:
mitochondria;
membrane potential;
traditional Chinese medicine;
cardiovascular diseases
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(12):242-250
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondrial membrane potential （MMP） is one of the most sensitive indicators of cell damage and one of the potential targets of traditional Chinese medicine （TCM） intervention in the cardiac function. Cardiovascular diseases， with complex mechanisms of the occurrence and development， often involve the myocardium and other organs and present slow development and high mortality， seriously affecting the quality of life of patients. The TCM treatment of cardiovascular diseases is praised for small side effects， low drug resistance， and holistic treatment and can effectively relieve symptoms and improve prognosis. In recent years， the research on the occurrence mechanism of cardiovascular diseases from mitochondrial function has gained increasing attention. MMP is closely related to the functioning mechanism of mitochondria. Studies have shown that TCM regulates MMP to treat cardiovascular diseases by modulating energy metabolism， improving mitochondrial structure and function， and inhibiting oxidative stress and apoptosis， thus protecting the heart function， improving the cure rate， and reducing the mortality of patients. This paper systematically reviews the studies about the mechanisms of TCM regulation of MMP in cardiovascular diseases including atherosclerosis， heart failure， myocardial ischemia-reperfusion injury， diabetic cardiomyopathy disease， and pulmonary artery hypertension. Most of Chinese medicine compound prescriptions， Chinese medicinal herbs， effective fraction， and active components can protect mitochondrial function by regulating MMP. However， relevant clinical trials and TCM theoretical studies of MMP remain to be carried out to provide more ideas for TCM treatment of cardiovascular diseases.
